My experience of monetisation is fairly limited, i run google adsense on quite a number of sites, so am familiar with that, i have also through this forum learned a bit more about affiliate marketing. So far neither of these methods seem ideal for my new site, we get visits from all over so im guessing affiliate sales would be tough, along with the hugely varying content needs. Adsense might be ok,  but payouts as we all know are very limited in all but the tougher niches, so the question is what way should i go?

I have the ability to place custom ads on each page individually, although as the site grows that will be quite tough to manage, i would also like something that can payout via a business paypal account.

My site is http://www.meknows.com

I am open to suggestions!

Thanks Dani, but can you give me an example of what sort of thing you mean?